Fever helps the immune system to battle infection

Fever confers survival benefits during infection. However, the underlying mechanism and the benefits for immune cells remained unclear until the latest publication from JianFeng Chen and collaborators in Immunity, also freshly reported in Nature.

They authors showed that fever promoted T lymphocyte transmigration and activation through the interaction of  two proteins: heat shock protein 90 (Hsp90) (which normally protects cells from stress) and α4 integrin. Interestingly, the researchers engineered mice harboring a mutated form of α4 integrin and who died rapidly following an infection with diarrhoea-causing bacteria.

Article in Nature Full article in Immunity